Dysosteogenesis in the Mandibular Bone of SAMP1/Klotho-Deficient Mice
À°Á¾ÀÎ, Toan Nguyen Khanh, ¼¿ä¼·, À¯»óÁØ, ¾È»ó°Ç,
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À°Á¾ÀÎ ( Yook Jong-In ) - Yonsei University College of Dentistry Department of Oral Pathology
( Toan Nguyen Khanh ) - Chosun University School of Dentistry Department of Oral Pathology
¼¿ä¼· ( Seo Yo-Seob ) - Chosun University School of Dentistry Department of Oral and Maxillofacial Radiology
À¯»óÁØ ( Yu Sang-Joun ) - Chosun University School of Dentistry Department of Periodontology
¾È»ó°Ç ( Ahn Sang-Gun ) - Chosun University School of Dentistry Department of Oral Pathology
Abstract
Aging is a physiological change that leads to a decline in biological functions from metabolic stress. To investigate the effect of aging on mandibular bone formation, we created SAMP1/Klotho-deficient mice and performed micro-computed tomography (micro-CT) and histology analyses in 4-or 8 week-old SAMP1/kl -/- mice. SAMP1/kl -/- mice exhibited extensive inflammation, tissue calcification, and abnormal mandibular bone development. Using micro-CT analysis, SAMP1/kl -/- mice displayed a loss of incisor roots and irregular dentinal tubule formation, as well as calcification within the pulp root canal. Furthermore, the mandibular ramus showed extensive ground glass appearance in SAMP1/kl -/- mice. In histological analysis, we found calcified skeletal structures and dysplastic bone formation in SAMP1/kl -/- mice. These results provide an understanding of the pathologic alterations of aging-related mandibular bone. SAMP1/kl -/- mice may serve as a novel model for dysosteogenesis in mandibular bone development.
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SAMP1/ Klotho; Aging; Dysosteogenesis; Mandibular bone; Bone development
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